An Investigation Into CD1a, a Versatile Antigen-Presenting Molecule

A public human population of TRAV26 type II natural killer T cells recognises CD1d in a lipid-independent manner

Kean Chan Yew Poa, Christopher M Harpur, Tan-Yun Cheng, Elena Batleska, Catriona V Nguyen-Robertson, Rajesh Lamichhane, Alison A White, Geovane Marques-Ferreira, Caroline Soliman, Scott JJ Reddiex, Christopher Menne, Adam P Uldrich, D Branch Moody, Jamie Rossjohn, Dale I Godfrey, Daniel G Pellicci, Jérôme Le Nours, Catarina F Almeida

2026-10-07

<jats:title>Abstract</jats:title> <jats:p> Most studies of CD1d-restricted natural killer T ..

Lipidomic scanning of self-lipids identifies headless antigens for natural killer T cells

Tan-Yun Cheng, T Praveena, Srinath Govindarajan, Catarina F Almeida, Daniel G Pellicci, Wellington C Arkins, Ildiko Van Rhijn, Koen Venken, Dirk Elewaut, Dale I Godfrey, Jamie Rossjohn, D Branch Moody

2024-08-01

To broadly measure the spectrum of cellular self-antigens for natural killer T cells (NKT), we developed a sensitive lipidomics sy..

CD1 displays its own negative regulators

A Shahine, I Van Rhijn, J Rossjohn, DB Moody

2023-08-01

After two decades of the study of lipid antigens that activate CD1-restricted T cells, new studies show how autoreactive αβ T-cell..